Effects of Stressor Controllability on Corticostriatal Activity
نویسندگان
چکیده
....................3 Introduction.................4 Methods.....................8 Results......................13 Discussion..................16 Acknowledgements.......19 References..................20 Figure/Table Legend......25 Figures/Tables.............28
منابع مشابه
Effects of stressor controllability on psychophysiological, cognitive and behavioural responses in patients with major depression and dysthymia
BACKGROUND The experience of uncontrollability and helplessness in the face of stressful life events is regarded as an important determinant in the development and maintenance of depression. The inability to successfully deal with stressors might be linked to dysfunctional prefrontal functioning. We assessed cognitive, behavioural and physiological effects of stressor uncontrollability in depre...
متن کاملInescapable shock induces resistance to the effects of dexamethasone.
Administration of bacterial endotoxin (lipopolysachharide; LPS) elevates proinflammatory cytokines, such as interleukin-1beta (IL-1beta) and IL-6, and activates the hypothalamic-pituitary-adrenal (HPA) axis. Corticosterone (CORT), the glucocorticoid (GC) effector hormone of the HPA axis in rats, inhibits both proinflammatory cytokine production/release and activity of the HPA axis itself. Expos...
متن کاملMales and females respond differently to controllability and antidepressant treatment.
BACKGROUND Women are much more likely to suffer from stress-related mental illness than men; yet few, if any, animal models for such sex differences exist. Previously, we reported that exposure to an acute stressor enhances learning in male rats yet severely impairs learning in female rats. Here, we tested whether these opposite effects in males versus females could be prevented by establishing...
متن کاملUnderstanding stress: characteristics and caveats.
Exposure to stressful situations is among the most common human experiences. These types of situations can range from unexpected calamities to routine daily annoyances. In response to stressors, a series of behavioral, neurochemical, and immunological changes occur that ought to serve in an adaptive capacity. However, if those systems become overly taxed, the organism may become vulnerable to p...
متن کاملHeterosynaptic Dopamine Neurotransmission Selects Sets of Corticostriatal Terminals
Dopamine input to the striatum is required for voluntary motor movement, behavioral reinforcement, and responses to drugs of abuse. It is speculated that these functions are dependent on either excitatory or inhibitory modulation of corticostriatal synapses onto medium spiny neurons (MSNs). While dopamine modulates MSN excitability, a direct presynaptic effect on the corticostriatal input has n...
متن کامل